Gene name:
SLC11A2 (OK/SW-cl.20;DCT1;DMT1;NRAMP2) ;
Protein name:
Natural resistance-associated macrophage protein 2 (NRAMP 2) ;
Alternative:
Divalent metal transporter 1 (DMT-1) ;Divalent cation transporter 1 ;Solute carrier family 11 member 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2.
Function:
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
Subcellular Location:
Endosome membrane
Multi-pass membrane protein
Protein Attributes:
50:
MVLGPEQKMS | DDSVSGDHGE | SASLGNINPA | YSNPSLSQSP | GDSEEYFATY |
100:
FNEKISIPEE | EYSCFSFRKL | WAFTGPGFLM | SIAYLDPGNI | ESDLQSGAVA |
150:
GFKLLWILLL | ATLVGLLLQR | LAARLGVVTG | LHLAEVCHRQ | YPKVPRVILW |
200:
LMVELAIIGS | DMQEVIGSAI | AINLLSVGRI | PLWGGVLITI | ADTFVFLFLD |
250:
KYGLRKLEAF | FGFLITIMAL | TFGYEYVTVK | PSQSQVLKGM | FVPSCSGCRT |
300:
PQIEQAVGIV | GAVIMPHNMY | LHSALVKSRQ | VNRNNKQEVR | EANKYFFIES |
350:
CIALFVSFII | NVFVVSVFAE | AFFGKTNEQV | VEVCTNTSSP | HAGLFPKDNS |
400:
TLAVDIYKGG | VVLGCYFGPA | ALYIWAVGIL | AAGQSSTMTG | TYSGQFVMEG |
450:
FLNLKWSRFA | RVVLTRSIAI | IPTLLVAVFQ | DVEHLTGMND | FLNVLQSLQL |
500:
PFALIPILTF | TSLRPVMSDF | ANGLGWRIAG | GILVLIICSI | NMYFVVVYVR |
550:
DLGHVALYVV | AAVVSVAYLG | FVFYLGWQCL | IALGMSFLDC | GHTCHLGLTA |
568:
QPELYLLNTM | DADSLVSR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Human NRAMP 2
ELISA Kit for Human NRAMP 2
ELISA Kit for Human NRAMP 2
CLIA Kit for Human NRAMP 2
CLIA Kit for Human NRAMP 2
CLIA Kit for Human NRAMP 2
Polyclonal Antibody for Human NRAMP 2
Polyclonal Antibody for Human NRAMP 2
Polyclonal Antibody for Human NRAMP 2
Monoclonal Antibody for Human NRAMP 2
Monoclonal Antibody for Human NRAMP 2
Monoclonal Antibody for Human NRAMP 2
Protein for Human NRAMP 2
Protein for Human NRAMP 2
Protein for Human NRAMP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 1-583 (ISOFORM 3);ALTERNATIVE SPLICING (ISOFORMS 2 AND 4);TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
tissue :
Brain .
tissue :
Thalamus .
tissue :
Trachea .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Colon adenocarcinoma .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
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tissue :
Neuroblastoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 58-568 (ISOFORM 1)
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Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : BIOPHYSICOCHEMICAL PROPERTIES;NIFEDIPINE TREATMENT
14.
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Cited for : INTERACTION WITH NDFIP1; NDFIP2 AND WWP2;SUBCELLULAR LOCATION
15.
"Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons."
Howitt J.
,
Putz U.
,
Lackovic J.
,
Doan A.
,
Dorstyn L.
,
Cheng H.
,
Yang B.
,
Chan-Ling T.
,
Silke J.
,
Kumar S.
,
Tan S.S.
Proc. Natl. Acad. Sci. U.S.A.106:15489-15494(2009)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : INTERACTION WITH NDFIP1 AND NEDD4L
16.
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Cited for : SUBCELLULAR LOCATION;FUNCTION;INTERACTION WITH COX2 AND TOM6
17.
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Cited for : VARIANT AHMIO1 ASP-399
18.
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Cited for : VARIANT AHMIO1 CYS-416
19.
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Cited for : VARIANTS AHMIO1 VAL-114 DEL AND VAL-212
20.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
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PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] THR-48